I originally did this with Maleficent and due to my recent activity with 101 Dalmatians I have decided to write a voting on Cruella De Vil. There have been many more versions of Cruella De Vil and a lot more on the way, especially with her appearance in Once Upon a Time and in her own movie that is yet to be put in production.
In a personal note, I think Glenn Close's Cruella De Vil was the most evil and scarier than the Cruella in the original animated movie, I use to get the chills by just looking at her picture. She was just real pure evil in the Live-Action films.