In Cars 2, the World Grand Prix is created by Miles Axlerod to promote his new clean fuel Allinol. The competition unites the 11 best racers of all race types to determine the world's fastest car. The event is composed of three races: Japan, Italy, and England.
The World Grand Prix is the target of a plot to sabotage the race directed by the evil weapons designer Professor Z. The British master spy Finn McMissile discovered the conspiracy and organized himself to stop it.
- Originally, the World Grand Prix was to be composed of five races. Paris would have hosted a "Le Mans-style 24-hour race", and in Germany's Black Forest a "DTM-style rally race" would have taken place. But these races were abandoned because it was too much story to tell. However, in the Nintendo DS version of Cars 2: The Video Game, they do appear.
- According to the country, the name "World Grand Prix" changes languages; for example, in Italy: Mondiale Grand Prix; in Japan: ワールドグランプリ (Wārudoguranpuri). There are also exceptions; for example, in Polish.
- The World Grand Prix has a mascot whose name was revealed to be Globie.
- There are no pit stops witnessed in any of the races but they are available such mentioned by Acer.
- London was chosen as one of the host cities of the World Grand Prix to coincide the 2012 Summer Olympics that would be held a year later.