Winnie is a wealthy girl that runs away from home and encounters the Tucks, a family of immortal beings. She develops a deep love for Jesse Tuck, a one-hundred-four-year-old boy trapped in a seventeen year old’s body for all of eternity. A greedy man known as The Man in the Yellow Suit has a plan based on childhood stories he heard from his grandmother about a family who could never die. He set out to find this family of immortals and sell the water they drank from for huge amounts of money. Mae Tuck foils his plans when she clubs him in the head with a shotgun. In the end of the film Winnie helps Mae escape from prison and chooses not to drink from the bottle but instead to die like all other mortals. In the late 1900s, Jesse rides up to the tree on a motorcycle and visits Winnie’s grave under the spring.
- Mrs. Foster: (while strapping Winnie into corset) "You must suffer to be beautiful, so say the French."
Winnie: "Well the French are crazy."
- Winnie: (turns on side and starts talking to a toad) "I need a new name. One that's not all worn out from being called so much."