The Manual of Witchcraft and Alchemy is an evil spellbook given to Winifred Sanderson by the Devil himself; bound in human skin, it contains the recipes for her most powerful and evil spells.
The book is written in blood, bound in skin, and contains a number of recipes and incantations. It has a human eye on the front cover, and often sleeps, only waking to the sound of its mistress who dotes on and cherishes it, meaning the book is alive and, on some level, intelligent. The book is protected by magic and thus cannot be burned or destroyed by traditional means. It is an unholy record of evil magic and nothing good can come from it.
Among its contents is the life potion, an evil potion that allows the sisters to suck the life-force of the drinker to replenish their youth. Other spells include cursing a victim with immortality, transforming victims into cats, raising the dead, cursing victims with boils and blisters, and numerous others.
Its most important curse was that if in the event the sisters were killed, that if a virgin lit the Black Flame Candle on Halloween during a full moon, the witches would return alive for one night unless they suck the life out of a child lest they turn to dust come sunrise.
After the sisters' deaths, it was last seen in the witches' cottage, opening its eye, and presumably remained there.