For Disney, she provided the voice of Innoko in Brother Bear 2. In 2011, Sykes was signed on to appear in The Muppets as Officer Ethel, interrogating the detained Muppet gang, but her scenes were cut. She also plays Daphne Lido in the ABC TV show Black-ish and voiced Shirley B. Awesome in Penn Zero: Part-Time Hero and Thea in Doc McStuffins. She voices Gregoria in Vampirina.
Her voice acting as well voicing characters in the animated films such as Stella the Skunk in DreamWork's Over the Hedge, Bessie the Cow in Nickelodeon's Barnyard and its spinoff TV series Back at the Barnyard, and Sid's Granny in Ice Age: Continental Drift and Ice Age: Collision Course.