For Disney, she provided the voice of Innoko in Brother Bear 2. In 2011, Sykes was signed on to appear in The Muppets as Officer Ethel, interrogating the detained Muppet gang, but her scenes were cut. She also played Daphne Lido in the ABC TV show Black-ish and voiced Shirley B. Awesome in Penn Zero: Part-Time Hero.
Her voice acting as well voicing characters in the animated films Over the Hedge (2006), Barnyard (2006), Rio (2011), Ice Age: Continental Drift (2012) and Ice Age: Collision Course (2016).