Toontown is the home of Mickey Mouse and his supporting cast in most of their modern appearances, having made its animated debut in the short Runaway Brain in 1995. Based on Mickey's Toontown at Disneyland, it has appeared in various media starring Mickey and his friends including television, films, video games and a wide array of promotional material (with the exception of most comics, which retain the concept of Mickey and Goofy living in Mouseton and Donald Duck residing in Duckburg).
As mentioned, the town serves as the home for Mickey Mouse and friends, though in the series House of Mouse, several characters from the Disney animated features canon have made appearances in Toontown, more specifically the town's nightclub on Main Street, the House of Mouse.
Goofy's House - The home of Goofy. As with Donald, Goofy's home takes on a number of different appearances, including an average home, a trailer in Mickey Mouse Works, and most frequently a large, sloppily built home with a stone chimney as featured in the theme parks.
Mortimer's House - The home of Mickey's rival Mortimer Mouse. In some Mickey Mouse Works cartoons, Mortimer lives next door to Mickey.
The city's name is actually rarely, if ever, mentioned within Mickey Mouse Works and House of Mouse.