"Thelma and Luis" is the forty-third episode of The Proud Family.
After flooding Felix's house, Papi is sent to a retirement home called Happy Endings. However, it is secretly an okra farm, where the residents are forced to work on the fields all day. When Penny and friends discover this, having come in before visiting hours, they attempt to reveal this to their parents, only for the farm to adequately camouflage itself during visiting hours. Only Sugar Mama believes them, noticing the difference in feet size between Papi and his impostor. The next night, Sticky, Zoey, LaCieniga, Penny, Dijonay, and Suga Mama go and rescue Papi. But while the two are taking a trip to Las Vegas, the farm's manager, Helga, discovers the breakout and ride out on a motorcycle, intent on retrieving Papi.
Some time later, Boulevardezs knock on the Prouds' door, revealing that they went back to Happy Endings before visiting hours and discovered the okra farm but no Papi. Penny's nervous reaction leads her and LaCieniga to confess about their breakout. Realizing that Sugar Mama and Papi are in danger, Sunset declares that she will put out an APB. Oscar suggests someone better - his friend Igloo, "World's Greatest Detective" - though Trudy reminds again that Igloo is a mall cop.
Igloo is on the phone with Oscar, saying that he has a lead. However, he doesn't have enough money to pay his informant, who runs off with his money, forcing Igloo to hang up and chase him.
In Vegas, Papi is eating a delectable feast, having not eaten in days. Suddenly, Helga enters the restaurant, forcing the pair to flee, but the villain gives pursuit. They pass by Igloo's car and a police car, who promptly give chase. The Prouds and Boulevardezs catch up in Felix's car. Pulling up alongside Sugar Mama's car, Oscar tells her to pull over, as the road ends at the edge of the Grand Canyon. Sugar Mama stops just before the edge, warning Helga not to come any closer or she'll take her star okra picker (Papi) right over the edge. Thankfully, LaCieniga grabs a megaphone and announces to Sugar Mama and Papi that they don't need to run anymore, as the truth about Happy Endings was exposed. As she says this, Helga is arrested. As Sugar Mama rejoices and hugs Papi, she accidentally shifts the car gear from Park to Drive, causing them to plunge down into the canyon. In a panic, they share one last kiss, only for the car to release a parachute with the likeness of Bobby painted on it, slowing their fall and allowing them to land safely. Papi then begins to despair as the parachute falls over his and Sugar Mama as their kiss continues.
The police then shut down Happy Endings and its indentured residents are released back to their families. Sunset assures everyone that Helga is going away for a long time and tells Papi that he'll always be welcomed in their home.