Pepper Ann Pearson is a nerdy and unpredictable 12-year-old 7th grade girl who attends Hazelnut Middle School and the titular protagonist of the animated series of the same name. Her arrogance is matched by her friends and family. She is best friends with Milo Kamalani and Nicky Little. Her mother is Lydia Pearson, and she has a little sister named Moose. Her grandma is Miss Chism. She often has elaborate fantasy sequences in which her reflection acts as her conscience during moral dilemmas. Pepper Ann has a crush on Craig Bean. At the end of the title sequence, Pepper Ann always finds something different under her desk (for the first season, it was always "five bucks", but later on in the series, the item would vary, e.g., a mood ring).
- Pepper Ann and her mother Lydia made a brief cameo near the end of the House of Mouse pilot episode "The Stolen Cartoons", when Tantor throws Pete out of the building, causing Lydia to warn Pepper Ann, "Don't touch the villain, dear." Notably, Pepper Ann and her mother are the only two characters created for a Disney TV cartoon to ever appear in that show, aside from Ludwig von Drake.