Penelope Ann Miller, sometimes credited as Penelope Miller, is an American actress who has appeared in numerous films and television shows.

For Disney, she played Barbara Henry in the Walt Disney's Wonderful World of Color episode, Ruby Bridges, Mrs. Elizabeth Louse "Betty Lou" Perkins in the 1992 Touchstone Pictures film The Gun in Betty Lou's Handbag, Fran Ferrara in Desperate Housewives, Elizabeth Grey in the ABC TV show Mistresses and Eve Carlin in the ABC TV show American Crime.