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Patricia T. Arquette (born April 8, 1968) is an American actress and director who is the older sister of David Arquette and is best known for her role as Allison DuBois on the NBC/CBS drama series Medium from 2005 to 2011.

She played Kathryn Barlow in the 2003 Disney adventure comedy-drama film, Holes. She also played Kathy O'Hara in the 1994 Touchstone Pictures film, Ed Wood and Havana in the Hollywood Pictures film Holy Matrimony.