The ride follows, very closely, the story of the film. The queue area is themed to a bus station with commercials of tourist spots within in the city of Monstropolis. Posters of Harryhausen's, a restaurant from the film, are placed in queue, hinting to a scene within the attraction. Guests board taxis on a journey through the streets of Monstropolis. A small television monitor in each of the three rows of the ride vehicle plays a clip of a tourism video that is interrupted with news that a deadly human child has entered Monstropolis. More scenes of the movie are recreated through audio-animatronics and smells, such as the faint smell of ginger in the Harryhausen's sushi bar scene. The attraction's ending features an Audio-Animatronic version of the CDA leader from the film, Roz, and she can "ask" the riders questions which are controlled by a park cast member backstage. Sometimes, Roz will also say "Young lady in the first row. Nice ears. What lovely ears you have". or "Young man in the first row. Nice ears! Are those your real ears"? She'll only say this when she recognizes guests who wear Mickey and Minnie Mouse ear hats.
In January 2005, it was announced that a similar attraction would be replacing the Meet the World show at Tokyo Disneyland. With a working title of "Monsters, Inc.: Ride n' Go Seek", the ride is set to debut in 2009, in the Tomorrowland section of the park. A budget of $88 million was given in the press release, suggesting that the new ride will be much more lavish and expansive than the dark ride at Disney's California Adventure. Also, a part of the larger budget will account for creating an entirely new ride system, which was not needed at Disney's California Adventure since the ride was simply an overlay. It is unknown what ride type the Japanese attraction will be - whether it is a dark ride like "Mike & Sulley to the Rescue!" or a thrill ride with Audio-Animatronics.