Mainframe is a Marvel Comics character that appears in Hulk and the Agents of S.M.A.S.H., voiced by Jeffrey Combs, and in Guardians of the Galaxy Vol. 2, voiced by Miley Cyrus. Mainframe is an android built by Tony Stark in order to help him protect the universe and defeat the forces of evil. Mainframe is equipped with all the powers and weapons of the Iron Man armor. Mainframe is connected to F.R.I.D.A.Y. so he/she can stay in contact with Tony Stark no matter how far away he/she is.

At one point, he ended up in space, where he befriended Yondu and formed the original team of Ravagers alongside Stakar Ogord, Aleta Ogord, KrugarrCharlie-27, and Martinex T'Naga.