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She played Samantha in the 1972 Disney family adventure drama film Napoleon and Samantha, Martha McIver in the 1973 Disney western film One Little Indian, Annabel Andrews in the 1976 Disney comedy film Freaky Friday and Casey Brown in the 1977 Disney family film Candleshoe. She also played Kyle Pratt in the 2005 Touchstone Pictures film Flightplan.
She is also best known for her role as Clarice Starling in the horror-thriller Silence of the Lambs in which she co-starred alongside Anthony Hopkins who played Hannibal Lecter.