Colonel Dr. Irina Spalko is the main antagonist of Indiana Jones and the Kingdom of the Crystal Skull.
A Soviet agent born in a small mountain village in the eastern regions of the Ukrainian Soviet Socialist Republic, she was believed by those in her village to be a witch as her apparent psychic powers began to manifest themselves through animal control.
An impressed Joseph Stalin inducted her into researching psychic warfare, awarding her with the Order of Lenin three times. She is skilled in fencing and hand-to-hand combat and is Indiana's main antagonist as she brings the crystal skull to Akator to utilize the power there for her country's militant purposes. Ironically, her desire for knowledge proved her undoing when the crystal skull entity grants her desire to know everything, and an alien figure emerges and indicates that Spalko was too dangerous to remain alive. Her mind overloads and she disintegrates as her scattered essence is teleported to another dimension.