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Invisible Sister is the comedy adventure story of Cleo (Rowan Blanchard), a tween girl whose science project goes terribly wrong, making her popular older sister, Molly (Paris Berelc), suddenly invisible!
- Rowan Blanchard as Cleo
- Paris Berelc as Molly
- Karan Brar as George, Cleo’s best friend and fellow science whiz kid
- Rachel Crow as Nikki, Molly's best friend and teammate
- Austin Fryberger as the Coug, Molly's goofy yet affable boyfriend
- Scott Reeves as Cleo's Father
- Jennifer Jalene as Cleo's Mother
- Alex Désert as Mr. Perkins
The film was officially announced on January 9, 2015, along with the casting of Paris Berelc and Rowan Blanchard as Molly and Cleo. On February 27, 2015 Karan Brar, Rachel Crow, and Austin Fryberger where cast as George, Nikki, and The Coug. On March Francesca Capaldi, Lexie Nielsen, and Kylie Finkbone were added to cast. Filming began on March 22, 2015.