House of Blues is an American chain of concert venues and restaurants, founded in 1992 in Cambridge, Massachusetts, by Isaac Tigrett and Dan Aykroyd. Since 2006, the chain has been owned and operated by Live Nation. Two of the chain's thirteen locations are located inside Disney theme park resorts:

• House of Blues Orlando, located at the Walt Disney World Resort, opened in 1997
• House of Blues Anaheim, located at the Disneyland Resort, opened in 2001

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