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Holden Radcliffe (portrayed by John Hannah) is a transhumanist who believes in the improvement of humanity through enhancement. Due to his studies of parasites, Fitz and Simmons seek his help with counteracting Hive's abilities, but he is kidnapped by Hive first to help recreate the original Kree experiment that created the Inhumans. After a S.H.I.E.L.D. raid on Hive's base, Radcliffe escapes and agrees to cooperate with Coulson and Talbot. After being acquitted, Holden begins work on transferring his artificial intelligence AIDA to a Life Model Decoy, an old S.H.I.E.L.D. project.