Monogram's early life prior to the events is unknown, other than he was a Major. A maximum of five years ago, he came across Dr. Doofenshmirtz's plot to take over the Tri-State Area with his new army of Norm Bots, so he sent out his best agent Perry the Platypus to stop Doof at all costs. Unfortunately, Monogram soon realized that he has underestimated Doofenshmirtz's true intelligence, as the latter managed to defeat Perry and transformed him into Platyborg before carrying out his plan successfully. Following the disappearance of many of his other animal agents during Doof's reign, the Agency was declare defunct and Monogram was forced to work for Doofenshmirtz, given the job of "Indentured Executive Assistant".
Despite Monogram being happy that Doofenshmritz is finally brought to justice, he is still somewhat upset over the loss of many of his animal agents during Doofenshmirtz's reign. Monogram later learns from Candace that Doofenshmirtz's wife Charlene is the one responsible for capturing the agents and turning them into cyborgs, similar to how Doofenshmirtz defeated Perry and turned him into Platyborg. He later attended the reunion of all the returned agents following the Doofenshmirtz family's escape. (Tales From the Resistance: Back to the 2nd Dimension).
Not much is known about Monogram's personality in the 2nd Dimension, other than that he is loyal to Doofenshmirtz. However, it is revealed that he wants to see Doofenshmirtz get arrested, as he tells the Firestorm Girls to "book him" when he returns to the 2nd Dimension.
Monogram is physically identical to his 1st Dimension counterpart. As an Indentured Executive Assistant, he wears all-purple clothing that makes him resemble an Arabian of some sort. When he tells the Firestorm Girls to arrest Doofenshmirtz, he is seen as wearing the clothes his 1st Dimension self wears.