Negative Zone is a location in the Marvel Comics Universe. It is made of anti-matter instead of regular matter. It is home to Blastaar and Annihilus. It was discovered by the Fantastic Four. It appeared in The Avengers: Earth's Mightiest Heroes. It was the site of a maximum security prison for supervillains created by Mr. Fantastic and Ant-Man. The prison became under attack by Annihilus and the insectoids that lived in this universe. Later the universe itself became the prison for Galactus. It reappeared again in Hulk and the Agents of S.M.A.S.H. as the site where the Leader was hiding and causing much attacks on Earth. As well as Blastaar and Annihilus' home and army against the Agents of S.M.A.S.H..