Domino is one of Dottie and Dipstick's puppies together with Oddball and Little Dipper. He has two notable ears that are dyed in black and white spots, thus giving him the name "Domino." Also, he has a blue (live-action)/red (cartoon) collar that has a domino hanging from it.
Domino first appears as a newborn puppy together with Oddball and Little Dipper. He is later seen when Oddball attempts to get "spots" from a wet-inked paper machine when she is suddenly flung out the window, but is seen hanging on to the windowsill. Domino and the other puppies go out and try to save her, to which they succeed. He is later shown near the end of the film at the bakery, where he and the other pups use the machinery to help Oddball bake Cruella into a cake.
Domino makes an appearance in the video game 102 Dalmatians: Puppies to the Rescue, which is based off the movie 102 Dalmatians. Domino and Oddball are the main characters of the game and have to rescue other puppies from being kidnapped by Cruella, after disobeying their parents of not getting involved. He has a red collar and his domino hangs vertically. He is voiced by Frankie Muniz in the game.
- One known issue about Domino is his collar. In 102 Dalmatians, he is seen wearing a blue collar, whereas in his cartoon form and merchandise, he wears a red collar. Though both collars feature a domino hanging from it.
- The video game was not completely based off the live-action film. Although their brothers and sisters were dognapped, he is also captured. In the video game, Domino and Oddball were the rescuers. In the film, although Dottie was captured, Dipstick was not. The game features a different timeline and an entirely different plot.
- Domino got his name from the pattern of spots on his ears.
- In some clip-arts Domino is seen with a spot on top of his head, but in some, there are none.