Donald's sister was first mentoined in the cartoon short 'Donald's Nephews', in which she sent her sons Huey, Dewey and Louie to visit Donald. In the comic adaptation of the short, it was told that the nephew's father was in the hospital after a giant firecracker had exploded under his chair, In this comic, Della was still said to be Donald's cousin, rather than his sister.
The nephews' mother made her first visual appearance in Mark Worden's illustrated version of Carl Barks' Duck family tree, by the name Thelma Duck, which was given to her by Barks. However, in Don Rosa's Duck Family Tree, she was given the first name Della again. Della later appeared as a kid alongside her brother and her parents in Rosa's 'The Empire-Builder from Calisota', chapter 11 of 'The Life and Times of Scrooge McDuck'. In this story, Rosa was the first to mention that Della and Donald are twins.
Della was one of the first female pilots, and eventually became an astronaut, leaving her children with her brother just before she left for a space trip, as mentoined in the Dutch comic '80 is prachtig'. This comic was made in honor of Donald Duck's 80th anniversary, and was published in a special issue.
- 'Della' is also the first name of Al Taliaferro's aunt.
- In an early translation of the comic adaptation of 'Donald's Nephews', Huey, Dewey and Louie were sent to Donald by Clarabelle Cow instead of his sister.
- Della made a very obscure cameo appearance in Don Rosa's 'The Sign of the Triple Distelfink'. During a flashback of Gladstone, she can be seen at young Gladstone's birthday party.
- Della's introduction was the first time a Sensational Six member was explicitly told to have a sibling (Morty and Ferdie's mother was already introduced in 1932, but she was said to be Mickey's sister years after their first appearance).