Part 1: "Road Warriors"
The Dearly family, plus the 101 Dalmatians, go on a second honeymoon. Unfortunately, Cruella tags along, threatening to fire Anita if she did not allow her to join. Worse, Roger and Anita learn that they are not legally married, because their minister was a conman.
Part 2: "Cross-Country Calamity"
Cruella does all she can to prevent the Dearlys from getting married, knowing that she will automatically get their farm if they fail to do so.
Part 3: "Dearly Beloved"
The pups try their best to help Roger find Anita, who is held captive by alien cultists who refuse to let her leave until their "Shaggy-Green Messenger" comes for them.
- This episode was released on video outside the US and on Laserdisc in Japan. In the US, it was only issued on VideoCD.
- The video version of the episode edits the three parts into one movie and features the songs "Dalmatian Vacation" and "Surf Puppies" which were not in the broadcast version. These songs were later added to the album The Music of One Saturday Morning in 1999.
- On the VHS cover, Two-Tone has more spots on her upper half than she usually does, Whizzer is drawn with Dipstick's character model, and Cadpig appears twice.
- For some reason, Disney Junior only aired the third part of the serial, but never aired the first or second parts. This could be due to some of the dark humor in the first part (such as Spot getting on a truck full of chickens who are on their way to a slaughter house, thinking that "It's so happy; chickens never come back!") that Disney Junior found too scary for preschoolers, and suggestive situations in the second part (Cruella putting on an inflatable "sexy girl on the beach" costume in order to seduce Roger) that they found too inappropriate for preschoolers.
- At one point, there's a reference to Wile E. Coyote and Roadrunner from Looney Tunes.