De Niro was cast as the young Vito Corleone in the 1974 film The Godfather Part II, for which he won the Academy Award for Best Supporting Actor. His longtime collaboration with director Martin Scorsese earned him the Academy Award for Best Actor for his portrayal of Jake LaMotta in the 1980 film Raging Bull. He received the AFI Life Achievement Award in 2003, the Golden Globe Cecil B. DeMille Award in 2010 , and the Presidential Medal of Freedom from President Barack Obama in 2016.
De Niro's first major film roles were in the sports drama Bang the Drum Slowly and Scorsese's crime film Mean Streets. He earned Academy Award nominations for the psychological thrillers Taxi Driver and Cape Fear, both directed by Scorsese. De Niro received additional nominations for Michael Cimino's Vietnam war drama The Deer Hunter, Penny Marshall's drama Awakenings, and David O. Russell's romantic comedy-drama Silver Linings Playbook. His portrayal of gangster Jimmy Conway in Scorsese's crime film Goodfellas, and his role as Rupert Pupkin in the black comedy film The King of Comedy, earned him BAFTA Award nominations.
De Niro has earned four nominations for the Golden Globe Award for Best Actor – Motion Picture Musical or Comedy, for his work in the musical drama New York, New York, the action comedy Midnight Run, the gangster comedy Analyze This, and the comedy Meet the Parents. Other notable performances include roles in Once Upon a Time in America, Brazil, The Mission, The Untouchables, Heat, and Casino. He has directed and starred in films such as the crime drama A Bronx Tale and the spy film The Good Shepherd.
- He was considered for the role of Judge Doom in Who Framed Roger Rabbit along with Tim Curry, John Cleese, Christopher Lee, Roddy McDowall, Robin Williams, Eddie Deezen, Sting, Jon Pertwee, John Lithgow, Willem Dafoe, John Malkovich, Gabriel Byrne, Tim Robbins, Michael Keaton, Alec Baldwin, Richard Gere, Dustin Hoffman, Al Pacino, Ron Perlman, and Jeff Goldblum.