She was a frequent visitor to the sets of Sesame Street, Saturday Night Live and The Muppet Show. Her father, Jerry Nelson, took some time off during the first season of The Muppet Show to spend more time with his daughter due to her health problems.
She had a cameo in The Great Muppet Caper alongside her father. Her mother, Jacquie Gordon, wrote a book about Christine called Give Me One Wish, in which it is stated that Jim Henson gave Christine a speaking part so she would become a member of the actors' union.
Christine died in 1982 while production for The Fantastic Miss Piggy Show started. Rye Country Day School, where she had attended, has an award named in her memory.