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The Centipede is a weapon developed by Raina and created by HYDRA which is composed of gamma radiation, Extremis, Super Soldier serum and Chitauri material. It appears in Marvel's Agents of S.H.I.E.L.D.
- Fireproof blood cells from Chan Ho Yin were later implanted into the Centipede which stabilizes the Extremis.
- For John Garrett only, Raina injected a synthesized GH-325 into Garrett.