When Bruno was a puppy, he was given to a younger Cinderella as a gift from her father. After the latter died, Bruno and Cinderella grew up together under the hand of her evil stepmother, Lady Tremaine, who has two daughters, Anastasia and Drizella, and a cat, Lucifer, whom Bruno hates because of the way he treats Cinderella and his taunting.
Apart from his friendly nature, Bruno is very loyal and understanding to Cinderella. However, he has little patience for Lucifer, whom he doesn't like, which usually causes him to get sent out of the house due to Lady Tremaine's rules. At the end of the first movie, he gets his revenge by scaring Lucifer out the window.
Bruno is a big dog with red-brown fur covering most of his body. He has a black nose, floppy ears, a tail, light-brown eyes, sharp nails that are usually always sticking out, and three little hairs like Goofy's on his head.
In the original film, Bruno is first shown sleeping in the kitchen, dreaming about chasing Lucifer. When Cinderella wakes him up, he is happy to see her, but she then tells him how it is bad that he has caught Lucifer in his dream and that he should learn to be nice to cats, which is an idea he does not like. She tries to point out that Lucifer has his good points, but she can't think of any, which causes Bruno to laugh at Lucifer's expense. Lucifer then scratches Bruno on the face, causing him to growl at him, and then Lucifer pretends that Bruno has hurt him, resulting in Cinderella sending Bruno outside.
In the middle of the movie, Bruno watches Cinderella run outside to the garden, wearing her torn-up dress (destroyed by Anastasia and Drizella due to the bead and sash which they threw away earlier), to cry on the bench nearby. He and Major look sad for the fact that she is not going to the ball. Then they see a fog with sparkling stars is heading to her, which turns out to be the entrance of her Fairy Godmother. Bruno is turned into a footman by her for Cinderella's coach to take her to the ball; on the stroke of midnight, when the spell is broken, he is turned back into his true from. With Cinderella, Major and the mice, he runs behind the bushes, away from the palace guards who go past the pumpkin and smash it. He is shown to be happy that Cinderella had fun at the ball and danced with Prince Charming.
Near the end of the film, Lady Tremaine has locked Cinderella in her bedroom, and Jaq and Gus have stolen the key from Lady Tremaine, but Lucifer has trapped it and Gus under a teacup before he can free her. Realizing that Bruno may be the one who can get rid of Lucifer, Cinderella tells her bird friends to fetch him and to allow Bruno to finally catch the cat he hates the most. They fly down to the shed and try to wake him up, with Major helping them. He then follows them as he rushes into the chateau and, after being helped by them to get inside, scrambles up the tower staircase to arrive just outside Cinderella's room, where he catches Lucifer. He then lets out a growl, scaring Lucifer into jumping out the window. He jumps on the windowsill to watch Lucifer fall to the ground below, finally getting back at him while allowing the mice to finally free Cinderella from her room. He is last seen joining her on her honeymoon.
A brown dog resembling Bruno makes a cameo at one scene of this one-shot Goofy cartoon. Having a bad dream while Goofy pretend to be dog his his sleep. James MacDonald reprises his role as Bruno in that cartoon.
Bruno appeared in Cinderella comic book stories, including the comic adaptation of the film itself.
In the second movie, Bruno has a much smaller role than he had in the first film. He appears only in the first segment, Aim to Please and is so happy about Cinderella returning to her castle from her honeymoon that he gives her a kiss in the face. The next morning, a sharp and snobbish woman named Prudence enters Cinderella's room, where she finds Bruno sleeping in Cinderella's bed; he licks her face in response.
- James MacDonald, who voiced Bruno in the original film, also provided the voices of Jaq and Gus and the second voice of Mickey Mouse. He would also later voice Humphrey Bear in the mid-1950's.
- Bruno was used against Lucifer at the end of the first movie, but for some reason, he was never used against Pom-Pom. In fact, Bruno is only seen twice in the second film.
- Bruno doesn't appear in the third movie, nor the live-action film. This could most probably due to budget cuts.
- He is one of several bloodhounds from Disney animated canon movies, including Trusty, Towser, Copper and Napoleon.