Boone Wiseman is Penn Zero's friend, part-time side kick and student. Boone is the brains of the group and the one with the common sense, despite it being a bit warped to normal reason. His parents are also part-time heroes. He use to have a severe form of Hydrophobia until he realized that he can swim and fear of speaking to audiences until is was suggested that he imagine the audience in their underpants. Boone is easily distracted with other tasks, very lazy and unreliable but in the end he can get the job done, for example in episode "Totally into Your Body", he accidentally took Penn's space on the teleporter and became the mission hero. He was able to save the day by studying the books in the sub and save Penn Zero from a deadly virus.
Boone easily says that he loves his best friend, and they have a great time goofing off with each other. Sometimes they don't get along as well, like when they're competing for the Princess's love in "That Purple Girl". Or when Penn gets upset at him in "The Fast and the Floor Rugs" and calls him a load, upsetting Boone, but recognizing some truth in Penn's words, he tricks Rippen and speedily thinks of a trick to save Penn from being annihilated. Constantly, Boone warmly accepts Penn's apologies and makes amends if he needs to. He is thankful for how much Penn believes in him when Boone has to face his fears. Just as Penn is always helping him, Boone gives Penn advice once in a while and cares for his safety and success.
Being friends with Sashi, Boone is easily scared by her aggression, but he likes spending time with her. However, his easygoing and passionate personality sometimes clashes with Sashi's no-nosense and very driven personality. He accuses her of being mean and finds her annoyance with him and Penn aggravating in "The Princess Most Fair". When Sashi laments she feels left out of Penn and Boone's close bond, however, Boone injects that she makes them a great team of three. In "Flurgle Burgle", Boone blames Sashi for Penn's fusion with the Flurgle, but as soon as he realizes how bad she feels about the situation, he reassures her that everyone makes mistakes sometimes. He genuinely cares for her, telling Penn about Sashi's parents not knowing her true job and teaming up with him to make her a congratulatory Flurgle cake.
Boone sees Rippen as an enemy, but he mostly isn't terrified of him. Instead, he'll comment on Rippen's choices and sometimes makes fun of him. He even tricks him in "The Fast and the Floor Rugs" by encouraging him to mess up his three wishes, the third wish's failure saving Penn from being annilihated. Rippen revealing that he actually is very fond of Pigoilet in "The Princess Most Fair" pleases Boone, yet is disappointed that Rippen won't change his grade.
While Larry is Boone's enemy, Boone and Larry get along well and, when together, often bounce off of each other's zany personality and thoughts. In "Flurgle Burgle", he is surprised at how powerful Larry's kick is and criticizes Larry's choice in adding a second row of chairs, finding Rippen and Larry's disagreement over it amusing. In The Bewildering Bout of the Astounding Automatons.
- As revealed in "North Pole Down", Boone takes a drama class.
- In "Chicken or Fish?", it's revealed that he is afraid of water, though he gets over it in the same episode.
- As revealed in "Defending the Earth", he is afraid of speaking in public.
- He loves making art of Pigoilet, making a painting of it in "Cereal Criminals" and creating a clay figure and magic carriage (while in Musical Fairytale World) in "The Princess Most Fair".
- Boone's musical taste includes classic rock and metal, though he enjoys anything with soul.
- In "Totally into Your Body", he takes on a mission as the hero due to an accident on the zap platform.
- In "Flurgle Burgle", Sashi points out that Boone, like Penn, has parents who are part-time heroes, though unlike Penn's parents, they are not trapped in the Most Dangerous World Imaginable.
- In "Save the Worlds", Boone can be seen singing the song with the same name while in the Musical Fairy Tale World.
- In "A Tale of Two Wizards" Boone reveals that he is allergic to Griffin.