He appeared as himself on The Muppet Show in episode 221, the Wonderful World of Disney episode "Mickey's 50" and NBC Salutes the 25th Anniversary of the Wonderful World of Disney. Bob Hope also appeared as an ice cream vendor in The Muppet Movie.
In June 2000, he spent nearly a week in a California hospital after being hospitalized for gastrointestinal bleeding. In August 2001, he spent close to two weeks in the hospital recovering from pneumonia. On July 27, 2003, two months after his 100th birthday, Bob Hope died at his home in Toluca Lake, Los Angeles. He was mentioned in the fourth episode of Agent Carter.