Blotlings come in different varieties, and there are also different varieties within those. Although all of the Blotlings serve the Shadow Blot, some are direct spawn of him, while others are former inhabitants of the Wasteland turned into blotlings. They can be found everywhere in the Wasteland, except in Mean Street, probably because this sector is under the protection of Oswald. They're very aggressive creatures, the fact is that they attack anything that is not a blotling. Although the Blotlings are mostly a mindless collective, some Blotlings like the Sweepers and false Shadow Blot are more intelligent than others.
The Blotlings are one of the main types of enemies encountered in the game. Mickey Mouse has the choice of either destroying a Blotling with thinner or turning it ally with the player using paint. Mickey can also use Bunny Children to devour the blotlings for him. After the Shadow Blot is freed from its prison, it spawns more Blotlings to attack, including a special type called Bloticles to suck the paint from all over Wasteland. Once the Blot is destroyed, the Blotling threat ceases.
In Epic Mickey 2: The Power of Two, the new Blotling, the Dropwing, replaces the Seer from the first game. Also, one-eyed Spatters appear in the game, controlling Blotworx from the inside. However, neither the Fake Shadow Blot nor the Bloticles reappear. So it appears the Paint rain didn't turn them all good or they somehow got tuned back to their evil way of living. However the new Blotling, the Dropwing, replaces the Seer and the one-eyed spatter may mean that those aren't the same one's in the first game. Perhapes the transformed toons can spawn blotlings themselves or some of the purple plot plubs were left after the Paint rain and spawned new blotlings. The originals were either hiding out, killed off or migrated to get away. Or maybe the Beettleworx turned them back. It's show in the first game that damage from an evil blotling will turn back a friendly blotling. We can suppose the blotlings driving the Blotworx is a sign that they have been enrolled by The Mad Doctor and are under his control or that of another. Apart from that there is no difference on how to fight them, you can even use Oswald's electricity to stun them for a while.
Apparently, the remaining Blotlings in the end of Epic Mickey were not affected by raining paint at the end of the game and wandered Wasteland until they found homes in Blot Alley and Disney Gulch.
Some Blotlings will not remain an ally if they lose paint. An example of this is when a befriended Spladoosh can revert to an enemy again after two hits from a miss-target from a Beetleworx or a large blotling like a Slobber.
If you use Thinner on a Blotling, it will melt into the ground. The way they melt, if reversed, may look like the way Spatters had spawned in earlier concept art by appearing as a bubbling dark pile then jumping out of the ground.
A reformed Blotling, although it will not directly target Mickey, can hit Mickey, which will cause damage if he gets in the way of an enemy Blotling that has been targeted by the reformed Blotling.
Blotlings with red eyes are much more dangerous than green-eyed Blotlings. They first appear after you come back from the Jungle and return to Tortooga (if you didn't get Starkey to leave the Jungle: by not defeating all the Beetleworx and Spladooshes). All Red-eyed Blotlings are also in the final levels (including "Inside the Blot").