In Stitch! The Movie, Experiment 221 (Sparky), after being activated by Lilo and Stitch, goes on a rampage by shorting out the power supplies inside and outside the hotel, until he is eventually captured in a glass vase by Stitch.
In "Melty", Nani starts her first day of work at her new job at the hotel. Meanwhile, Lilo and Stitch, while meddling with time travel, make several attempts to capture Experiment 228 (Melty) at the hotel. In one alternate timeline, the hotel is destroyed by Melty. In another timeline it was destroyed when a cruise ship crashed into it. In another timeline it was destroyed by Gantu.
In "Swirly", a popular TV show called "Look at this!" broadcasts from this hotel.
In the crossover episode "Lax", the kids from Recess drop by for a visit and later spend some time at the hotel along with Stitch, after Stitch and most of the Recess Gang get zapped by Experiment 285's (Lax's) laziness-inducing ray.