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Big Business is a 1988 American comedy film starring Bette Midler and Lily Tomlin. It is the story of two sets of twins who were mismatched at birth, resulting in one being raised by a poor family and the other by a wealthy family.
- Bette Midler — Sadie Shelton/Sadie Ratliff
- Lily Tomlin — Rose Ratliff/Rose Shelton
- Fred Ward — Roone Dimmick
- Michael Gross — Dr. Jay Marshall
- Edward Herrmann — Graham Sherbourne
- Barry Primus — Michael
- Michele Placido — Fabio Alberici
- Seth Green — Jason
- Daniel Gerroll — Chuck
- John Hancock — Harlan
- Deborah Rush — Binky Shelton
- Nicolas Coster — Hunt Shelton
- J. C. Quinn — Garth Ratliff
- Joe Grifasi — Desk Clerk
- John Vickery — Hotel Manager
- Mary Gross — Judy