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Anne Hampton "Annie" Potts is an American actress. She is best known for her film role as Janine Melnitz in the 1984 science-fiction comedy film Ghostbusters and its 1989 sequel. She is also best known for her television roles as Mary Jo Shively on the CBS sitcom Designing Women from 1986 to 1993, Louanne Johnson in Dangerous Minds, Mary Elizabeth "M.E." Sims on the Lifetime drama series Any Day Now from 1998 to 2002, and as Gigi Stopper on the ABC comedy-drama series GCB in 2012.