- March 5 - Alice in Wonderland, directed by Tim Burton and starring Mia Wasikowska and Johnny Depp, was released in theaters.
- March 26 - Waking Sleeping Beauty
- May 28 - Prince of Persia: The Sands of Time
- June 18 - Toy Story 3, the third film in the Disney/Pixar film series starring Tom Hanks and Tim Allen, was released in theaters.
- July 15 - The Sorcerer's Apprentice, directed by Jon Turtletab and starring Jay Baruchael, was released in theaters
- October 8 - Secretariat
- November 24 - Tangled, the 50th animated Disney film was released in theaters, where it was well received by critics and audiences alike grossing over $590 million worldwide.
- December 17 - Tron: Legacy, the sequel to the 1982 film Tron, was released in theaters.
- February 13 - Kick Buttowski: Suburban Daredevil premieres on Disney XD
- April 4 - Good Luck Charlie premieres on the Disney Channel
- July 6 - Stitch! ~Zutto Saikō no Tomodachi~ (~Best Friends Forever~) premieres on TV Asahi and Disney Channel Japan
- August 2 - Phineas and Ferb: Summer Belongs to You! airs on Disney XD
- August 8 - Stitch! ~Itazura Alien no Daibōken~ (~The Mischievous Alien's Great Adventure~) airs its final episode
- September 24 - Fish Hooks officially premieres on the Disney Channel
- November 7 - Shake it Up premieres on the Disney Channel
- Spring - The Muppet Snow White mini-series is published
- June 16 - Darkwing Duck returns in a new comic book series from Boom! Studios
- September - Mickey Mouse and Friends publishes its 300th issue
- December 2 - Chip 'n Dale Rescue Rangers returns in a new comic book series from Boom! Studios
- November - A preview issue of Phineas and Ferb magazine is published
- January 5 - Cars Read-Along Storybook and CD, Cinderella Read-Along Storybook and CD, Toy Story Read-Along Storybook and CD, Winnie the Pooh: The Easter Egg Hunt Read-Along Storybook and CD
- January 19 - Phineas and Ferb Laughapalooza Joke Book
- April 6 - Kingdom Keepers III: Disney in Shadow
- May 4 - Beauty and the Beast Read-Along Storybook and CD, Toy Story 2 Read-Along Storybook and CD, and Toy Story 3 Read-Along Storybook and CD
- May 26 - The Art of Toy Story 3
- July 20 - The Princess and the Frog Read-Along Storybook and CD and Tinker Bell Read-Along Storybook and CD
- July 27 - Mickey's Spooky Night Read-Along Storybook and CD, Phineas and Ferb: Haunted Hayride
- August 3 - Two Guys Named Joe: Master Animation Storytellers
- August 10 - Tinker Bell and the Great Fairy Rescue Read-Along Storybook and CD
- August 31 - Tale as Old as Time: The Art and Making of Beauty and the Beast
- September 7 - Phineas and Ferb: Thumbs Up!
- September 14 - The Vault of Walt, Beauty and the Beast: The Enchanted Christmas Read-Along Storybook and CD, Tangled Read-Along Storybook and CD
- October 1 - Disneystrology
- November 17 - The Art of Tangled
- December 28 - Cinderella: A Heart Full of Love Read-Along Storybook and CD and The Little Mermaid Read-Along Storybook and CD
- January 9 - Kingdom Hearts Birth by Sleep (Japan)
- March 23 - Stitch Jam
- August 31 - Guilty Party
- September 7 - Kingdom Hearts Birth by Sleep (North America)
- September 14 - Phineas and Ferb Ride Again
- October 7 - Kingdom Hearts Re:coded (Japan)
- October 23 - Disney Channel All Star Party
- November 23 - Tangled
- November 30 - Epic Mickey
- January 22 - Sweet Duffy 2010; ShellieMay debuts at Tokyo DisneySea.
- February 23 - Captain EO reopens as Captain EO Tribute following the death of Michael Jackson, replacing Honey, I Shrunk the Audience.
- March 20 - My Friend Duffy debuted at Cape Cod Cook-Off at the Cape Cod section of American Waterfront at Tokyo DisneySea.
- May 9 - Honey, I Shrunk the Audience closes at Epcot.
- May 29 - Silly Symphony Swings opens at Disney California Adventure.
- June 11 - World of Color premieres at Disney California Adventure.
- June 12 - Captain EO reopens at Disneyland Paris.
- July 1 - Captain EO reopens at Tokyo Disneyland.
- July 2 - Captain EO reopens at Epcot.
- August 17 - Toy Story Playland opens at the Walt Disney Studios Park.
- September 7 - Maliboomer closes at Disney California Adventure.
- September 12 - Hong Kong Disneyland begins to celebrate its 5th anniversary.
- October 14 - Duffy the Disney Bear debuts at Treasures in Paradise in Paradise Pier at Disney California Adventure.
- October 14 - Duffy the Disney Bear debuts near the entrance to World Showcase at Epcot.
- November 19 - Duffy the Disney Bear debuts at Hong Kong Disneyland, as part of its Christmas celebrations.
- January 12 - The Lion King On Broadway, Disney Princess Party
- February 9 - StarStruck
- March 2 - Alice in Wonderland
- March 9 - Disneymania, Vol. 7
- March 16 - Bayou Boogie: Toe Tappin' Tunes Inspired by The Princess And The Frog
- March 30 - Disney Karaoke: Phineas and Ferb
- May 25 - Prince of Persia: The Sands of Time
- June 15 - Toy Story Favorites
- July 20 - Jonas L.A.
- August 10 - Camp Rock 2: The Final Jam
- August 24 - Disney Villains: Simply Sinister Songs
- September 7 - Playhouse Disney: Let's Dance
- September 14 - Beauty and the Beast
- September 21 - Phineas and Ferb Holiday Favorites
- October 5 - Sonny With a Chance
- October 19 - Hannah Montana Forever
- January 13 - Isamu Tanonaka (Japanese voice actor)
- January 17 - Daisuke Gōri (Japanese voice actor, narrator and actor)
- March 18 - Fess Parker (actress)
- April 6 - Eddie Carroll (voice actor)
- April 25 - Dorothy Provine (singer, dancer, actress and comedienne)
- May 2 - Lynn Redgrave (actress)
- May 9 - Lena Horne (singer, actress, civil rights activist and dancer)
- May 24 - Eugenia Paul (actress and dancer)
- June 29 - Ron Gans (voice actor)
- July 1 - Ilene Woods (voice actress)
- July 17 - Pres Romanillos (animator)
- July 29 - Lorene Yarnell (mime actor)
- September 1 - Cammie King (former child actress)
- September 11 - Harold Gould (actor)
- September 22 - Van Snowden (puppeteer)
- October 28 - James MacArthur (actor)
- November 28 - Leslie Nielsen (actor and comedian)
- January 12 - Like Stars on Earth
- January 26 - I [Heart] Jonas
- February 2 - Air Bud: Golden Receiver: Special Edition
- March 9 - Hannah Montana: Miley Says Goodbye?
- March 16 - The Princess and the Frog
- March 23 - Toy Story and Toy Story 2 (Blu-ray)
- March 30 - Alice in Wonderland (1951): Special Un-Anniversary Edition
- April 6 - My Friends Tigger & Pooh: Super Duper Super Sleuths
- April 13 - The Great Mouse Detective: Mystery in the Mist Edition
- April 20 - Handy Manny: Big Race
- May 11 - Toy Story and Toy Story 2 (DVD)
- June 1 - Alice in Wonderland (2010)
- June 8 - Starstruck: Extended Edition
- June 15 - Air Bud: World Pup: Special Edition
- July 1 - Oliver & Company: Special Edition Blu-ray + DVD
- August 3 - James and the Giant Peach: Special Edition Blu-ray + DVD
- September 7 - Camp Rock 2: The Final Jam
- September 14 - Prince of Persia: The Sands of Time and The Black Cauldron: 25th Anniversary Edition
- September 21 - Tinker Bell and the Great Fairy Rescue
- October 5 - Beauty and the Beast: Diamond Edition; Phineas and Ferb: A Very Perry Christmas
- October 26 - Have a Laugh!: Volume 1 and 2
- November 2 - Toy Story 3; Hannah Montana Forever: Who is Hannah Montana?; Mater's Tall Tales
- November 16 - A Christmas Carol; Mickey Mouse Clubhouse: Numbers Roundup; Handy Manny: Big Construction Job
- November 23 - The Search for Santa Paws
- November 30 - The Sorcerer's Apprentice; Fantasia & Fantasia 2000: 2 Movie Collection; Waking Sleeping Beauty; Walt & El Grupo
- May 27 - Open Vault Disney starts
- January 9 - Terra, Ventus, Aqua, Master Xehanort, Vanitas, Master Eraqus, Unversed, Braig, Dilan, Even, Ienzo, Lea, Isa
- January 22 - ShellieMay
- February 13 - Kick Buttowski, Gunther Magnuson, Brad Buttowski, and other characters, two new Fireside Girls
- February 27 - Albert
- March 5 - Alice Kingsleigh, Tarrant Hightopp, The Red Queen, The White Queen, The Knave Of Hearts
- March 8 - Khaka Peu Peu
- June 18 - Lots-o'-Huggin' Bear, Bonnie, Big Baby, Ken Carson, Stretch, Chunk, Sparks, Chuckles the Clown
- July 16 - Balthazar Blake, Dave Stutler, Becky Barnes, Veronica Gorloisen, Maxim Horvath, Morgana le Fay, and Abigail Williams
- August 2 - Klimpaloon
- September 3 - Milo the Fish, Oscar the Fish, Bea Goldfishburg, Jocktopus Ludwig Vandenbush
- October 1 - Melissa
- November 24 - Flynn Rider, Rapunzel, Maximus, Pascal, Pub Thugs, Mother Gothel, The King, The Queen, Captain of the Guard, The Stabbington Brothers
- December 17 - Sam Flynn, Quorra, CLU, Rinzler, Jarvis, Castor, Gem